Psilocybin Mushrooms
Magic mushrooms
Psilocybin-containing fungi with intense psychological effects, high anxiety potential and serious legal restrictions in most jurisdictions.
Key caution
Psychological distress, panic reactions and difficult psychological experiences are documented risks — particularly at higher exposures
Education profile
High-risk education profile
This profile is provided for risk awareness and educational context only. It is not a use guide.
SubsAtlas does not provide dosing, sourcing, preparation or optimization guidance.
Editorial review status — shown for transparency
AI Context
Deterministic summaries of curated archive data. Not medical advice. Not a use guide.
This is a high-risk education profile. AI Context does not provide use guidance, dosing or combination recommendations.
Psilocybin Mushrooms: profile overview
Psilocybin Mushrooms is a fungi with moderate evidence quality and a high risk profile. Psilocybin-containing fungi with intense psychological effects, high anxiety potential and serious legal restrictions in most jurisdictions. Individual responses vary significantly. This summary is drawn from the curated SubsAtlas archive.
- Risk profile: High — high concern — serious interaction risks, dependency potential or toxicity concerns.
- Evidence quality: Moderate — some research exists but results are mixed or populations differ.
- Key caution: Psychological distress, panic reactions and difficult psychological experiences are documented risks — particularly at higher exposures
- Interaction concerns noted with: MAOIs, Lithium, Alcohol.
- Primary compounds: Psilocybin, Psilocin.
Psilocybin Mushrooms is a high-risk education profile. AI Context does not provide use guidance.
Limitations
- Based on curated SubsAtlas archive data only.
- Not medical advice. Not legal advice. Not a use guide.
- Individual responses vary. Source review is ongoing.
- Do not rely on this for personal decisions.
AI Context summarizes curated SubsAtlas archive data only. Not medical advice. Not legal advice. Not a use guide. No external AI calls are made.
Quick Facts
Concise educational context for orientation. Effects and risks vary.
Category
fungi
Main compounds
Psilocybin, Psilocin
Reported profile
Altered visual and auditory perception, Emotional shifts — both positive and distressing, Altered sense of time, Nausea at onset, Psychological distress at high exposures
Onset range
General context varies
Duration range
General educational range only
Main caution
Psychological distress, panic reactions and difficult psychological experiences are documented risks — particularly at higher exposures
Body & Mind Map
Visual summary of reported effect patterns. Effects vary.
Community Signal
Community Signal is based on anonymous structured reports. It does not represent a recommendation.
Common warning
Preview signal — not from live moderated reports. Psychological effects can be intense, distressing and highly unpredictable.
Risk awareness
Clear cautions, uncertainty and interaction concerns. This is not medical advice.
Main risks
- Psychological distress, panic reactions and difficult psychological experiences are documented risks — particularly at higher exposures
- Adverse mental health outcomes are elevated in those with personal or family history of psychosis or mood disorders
- Psilocybin can trigger or worsen underlying mental health conditions — individual vulnerability is not always apparent in advance
- Controlled substance in most jurisdictions — serious legal consequences in most regions
- Wild foraging carries risk of poisoning from misidentification of toxic species — do not forage without expert botanical identification
- Do not drive or operate machinery — significant impairment of perception, coordination and judgment
Avoid if…
- You have relevant medical concerns without professional guidance
- You are in an unsafe setting
- You need to drive or operate machinery
Do not combine with…
- MAOIs
- Lithium
- Alcohol
- Other psychoactives
- Medications affecting serotonin
Medical caution
- Review medication interactions with a qualified professional
- Seek professional help for medical concerns
Unknowns
- Product quality may vary
- Individual response varies
- Evidence may be incomplete
Interaction Warnings
Interaction concerns are shown for risk awareness only. SubsAtlas does not describe any combination as safe.
- Psilocybin combined with MAOIs may intensify effects significantly and carries serotonin syndrome risk. Combining with lithium has been associated with adverse outcomes in documented cases. Combination with other psychoactives increases unpredictability and psychological distress risk.
Related safety topics
Educational context pages relevant to this profile. For risk awareness only.
General onset
General context varies
Peak
Varies by substance, product and person
Duration
General educational range only
After effects
May vary; monitor uncertainty and risk context
Timeline ranges are general educational context, not instructions.
Sources
Evidence quality, source type and review context are separated from community patterns.
Sources need editorial review
Sources listed here have not yet completed editorial review. They are shown for transparency, not as verified citations. What source review means
Curated psilocybin mushroom profile
editorial source · Reviewed 2026-05-16
Source status: needs-review · How source review works
Legal context
Legal status varies by country, state and local regulation. This is educational context only — not legal advice.
Psilocybin mushrooms are controlled substances in most countries and jurisdictions, with regulated exceptions emerging in some regions for supervised clinical or therapeutic contexts. Possession and use is prohibited in most regions. This profile is for educational context only.
Legal status varies by country, state and local regulation. SubsAtlas provides educational context only and does not provide legal advice, sourcing or buying guidance.
Legal context requires ongoing review as laws change. How legal context works
Similar Entries
Related educational profiles for comparison and context.
Amanita Muscaria
High-caution fungus with a distinct pharmacological profile from psilocybin mushrooms. Misidentification and ibotenic acid toxicity are serious risks.
Not the same as psilocybin mushrooms — different compounds, different pharmacology, different risk profile
Legal: Legal context varies
THC
Primary intoxicating cannabinoid in cannabis. Clear impairment risks, dependence potential and adverse mental health outcomes at high-dose or regular use.
Main caution
Impaired memory, attention and psychomotor function — do not drive or operate machinery
Legal: Legal context varies
Blue Lotus
Botanical associated with calm and dreamlike reports, with limited evidence and product-quality uncertainty.
Main caution
Limited evidence
Legal: Legal context varies
Partner Resources
Education resources editorially separate from risk ratings and evidence content.
High-risk education profiles do not include commercial product recommendations. Only education, evidence literacy and recovery resources are shown.
How to Change Your Mind
Partner resourceEducation Partner · Book
Michael Pollan's landmark work exploring the science, history and cultural context of psychedelic research. An accessible, evidence-aware overview for general audiences.
Partner link. We may earn a commission. Editorial content remains independent.
Risk ratings and evidence levels are not influenced by partners.
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Pharmacology: An Introduction
PreviewEducation Partner · Course
OpenStax-aligned pharmacology learning resource covering receptor mechanisms, drug classes and physiological effects. Suitable for general audiences seeking scientific foundations.
Partner link. We may earn a commission. Editorial content remains independent.
Risk ratings and evidence levels are not influenced by partners.
Partner resource preview — not yet active
Partner resources never affect risk ratings or evidence levels. Disclosure policy
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Educational information only. Not medical advice. No personalized dosing, sourcing, preparation or optimization guidance.