What not to mix with alcohol
Interaction concerns for alcohol combinations
Alcohol has serious interaction concerns with opioids, benzodiazepines, GHB and other CNS depressants. Educational context on known risk patterns — not a guide to combinations.
Interaction concern
High concernGeneral educational visualization, not a medical prediction.
Main cautions
Alcohol with CNS depressants produces additive respiratory depression
Alcohol + GHB is a documented severe interaction concern
High concern — review interaction concerns carefully. Not a use guide.
Educational context only. Not a use guide.
Risk signal is a general educational visualization based on profile risk levels and known interaction concerns. It is not a medical prediction.
How risk signal works →Legal status varies by country, state and local regulation. Cards are educational context only. How legal context works
Explore related profiles
Full educational profiles for the substances in this card.
Alcohol
Legal CNS depressant with well-documented impairment, dependence, organ health risks and extensive interaction concerns across many substances and medications.
Impaired judgment and coordination — do not drive or operate machinery
Legal: Legal context varies
GHB
High-risk depressant profile focused on sedation, overdose, dependence and alcohol interaction concerns.
Extremely narrow margin between sedating and overdose amounts — a defining safety concern
Legal: Restricted / controlled
Alprazolam / Xanax
High-risk benzodiazepine profile focused on sedation, dependence, withdrawal and depressant interaction concerns.
High dependence potential — withdrawal can be medically serious or life-threatening
Legal: Prescription-only
Heroin
High-risk opioid profile focused on overdose, dependence, sedation and depressant interaction concerns.
High overdose risk — respiratory depression can be fatal
Legal: Prohibited in many regions
Fentanyl
High-risk opioid profile focused on extreme overdose risk, respiratory depression and depressant interactions.
Extreme overdose risk — respiratory depression can be fatal
Legal: Prescription-only
Related safety topics
Educational context pages relevant to this card.
Educational information only. Not medical advice. Risk signal is a general educational visualization — not a medical prediction. Cards are not use guides or recommendations.